MBGE SEMINAR by Dr. Hind Medyouf

How do tumor cells exploit the microenvironment to promote cancer progression? Over the last decades, our understanding of cancer has undeniably evolved from a tumor cell centric view towards a more comprehensive “tissue-like” picture integrating extrinsic cues from the surrounding tumor microenvironment (TME) to shape a local ecosystem that favors the acquisition of the so called “hallmarks of cancer”. This has fueled the idea that deciphering the TME signals cancer cells rely on, could help unravel tumor vulnerabilities and pave the way to new treatment opportunities. However, such niche-dependencies do not follow a “one size fits all” pattern but are rather “made to tailor” as they can be highly dependent on the cancer type, disease stage, organ site as well as dynamically evolving niche functions (e.g., because of physiological aging)...

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